diff --git a/Content.Client/Access/UI/GroupedAccessLevelChecklist.xaml.cs b/Content.Client/Access/UI/GroupedAccessLevelChecklist.xaml.cs
index da68653ce5..4f07c31009 100644
--- a/Content.Client/Access/UI/GroupedAccessLevelChecklist.xaml.cs
+++ b/Content.Client/Access/UI/GroupedAccessLevelChecklist.xaml.cs
@@ -15,6 +15,8 @@ namespace Content.Client.Access.UI;
 [GenerateTypedNameReferences]
 public sealed partial class GroupedAccessLevelChecklist : BoxContainer
 {
+    private static readonly ProtoId<AccessGroupPrototype> GeneralAccessGroup = "General";
+
     [Dependency] private readonly IPrototypeManager _protoManager = default!;
 
     private bool _isMonotone;
@@ -63,7 +65,7 @@ public sealed partial class GroupedAccessLevelChecklist : BoxContainer
 
         // Ensure that the 'general' access group is added to handle
         // misc. access levels that aren't associated with any group
-        if (_protoManager.TryIndex<AccessGroupPrototype>("General", out var generalAccessProto))
+        if (_protoManager.TryIndex(GeneralAccessGroup, out var generalAccessProto))
             _groupedAccessLevels.TryAdd(generalAccessProto, new());
 
         // Assign known access levels with their associated groups
diff --git a/Content.Client/Delivery/DeliveryVisualizerSystem.cs b/Content.Client/Delivery/DeliveryVisualizerSystem.cs
index 846688149f..d5afd34533 100644
--- a/Content.Client/Delivery/DeliveryVisualizerSystem.cs
+++ b/Content.Client/Delivery/DeliveryVisualizerSystem.cs
@@ -24,7 +24,7 @@ public sealed class DeliveryVisualizerSystem : VisualizerSystem<DeliveryComponen
 
         if (!_prototype.TryIndex<JobIconPrototype>(job, out var icon))
         {
-            SpriteSystem.LayerSetTexture((uid, args.Sprite), DeliveryVisualLayers.JobStamp, SpriteSystem.Frame0(_prototype.Index("JobIconUnknown")));
+            SpriteSystem.LayerSetTexture((uid, args.Sprite), DeliveryVisualLayers.JobStamp, SpriteSystem.Frame0(_prototype.Index(UnknownIcon).Icon));
             return;
         }
 
diff --git a/Content.Server/Botany/Systems/MutationSystem.cs b/Content.Server/Botany/Systems/MutationSystem.cs
index 37b68d9475..ee35db48e3 100644
--- a/Content.Server/Botany/Systems/MutationSystem.cs
+++ b/Content.Server/Botany/Systems/MutationSystem.cs
@@ -9,13 +9,15 @@ namespace Content.Server.Botany;
 
 public sealed class MutationSystem : EntitySystem
 {
+    private static ProtoId<RandomPlantMutationListPrototype> RandomPlantMutations = "RandomPlantMutations";
+
     [Dependency] private readonly IRobustRandom _robustRandom = default!;
     [Dependency] private readonly IPrototypeManager _prototypeManager = default!;
     private RandomPlantMutationListPrototype _randomMutations = default!;
 
     public override void Initialize()
     {
-        _randomMutations = _prototypeManager.Index<RandomPlantMutationListPrototype>("RandomPlantMutations");
+        _randomMutations = _prototypeManager.Index(RandomPlantMutations);
     }
 
     /// <summary>
diff --git a/Content.Server/Cluwne/CluwneSystem.cs b/Content.Server/Cluwne/CluwneSystem.cs
index 73476ece17..2bad4e0b96 100644
--- a/Content.Server/Cluwne/CluwneSystem.cs
+++ b/Content.Server/Cluwne/CluwneSystem.cs
@@ -21,6 +21,8 @@ namespace Content.Server.Cluwne;
 
 public sealed class CluwneSystem : EntitySystem
 {
+    private static readonly ProtoId<DamageGroupPrototype> GeneticDamageGroup = "Genetic";
+
     [Dependency] private readonly PopupSystem _popupSystem = default!;
     [Dependency] private readonly SharedAudioSystem _audio = default!;
     [Dependency] private readonly IRobustRandom _robustRandom = default!;
@@ -53,7 +55,7 @@ public sealed class CluwneSystem : EntitySystem
             RemComp<CluwneComponent>(uid);
             RemComp<ClumsyComponent>(uid);
             RemComp<AutoEmoteComponent>(uid);
-            var damageSpec = new DamageSpecifier(_prototypeManager.Index<DamageGroupPrototype>("Genetic"), 300);
+            var damageSpec = new DamageSpecifier(_prototypeManager.Index(GeneticDamageGroup), 300);
             _damageableSystem.TryChangeDamage(uid, damageSpec);
         }
     }
diff --git a/Content.Server/Destructible/Thresholds/Behaviors/WeightedSpawnEntityBehavior.cs b/Content.Server/Destructible/Thresholds/Behaviors/WeightedSpawnEntityBehavior.cs
index e02ed87322..96fa4dd438 100644
--- a/Content.Server/Destructible/Thresholds/Behaviors/WeightedSpawnEntityBehavior.cs
+++ b/Content.Server/Destructible/Thresholds/Behaviors/WeightedSpawnEntityBehavior.cs
@@ -19,6 +19,8 @@ namespace Content.Server.Destructible.Thresholds.Behaviors;
 [DataDefinition]
 public sealed partial class WeightedSpawnEntityBehavior : IThresholdBehavior
 {
+    private static readonly EntProtoId TempEntityProtoId = "TemporaryEntityForTimedDespawnSpawners";
+
     /// <summary>
     /// A table of entities with assigned weights to randomly pick from
     /// </summary>
@@ -64,7 +66,7 @@ public sealed partial class WeightedSpawnEntityBehavior : IThresholdBehavior
         if (SpawnAfter != 0)
         {
             // if it fails to get the spawner, this won't ever work so just return
-            if (!system.PrototypeManager.TryIndex("TemporaryEntityForTimedDespawnSpawners", out var tempSpawnerProto))
+            if (!system.PrototypeManager.TryIndex(TempEntityProtoId, out var tempSpawnerProto))
                 return;
 
             // spawn the spawner, assign it a lifetime, and assign the entity that it will spawn when despawned
diff --git a/Content.Server/EntityEffects/EntityEffectSystem.cs b/Content.Server/EntityEffects/EntityEffectSystem.cs
index e18b3b1470..54270ca53d 100644
--- a/Content.Server/EntityEffects/EntityEffectSystem.cs
+++ b/Content.Server/EntityEffects/EntityEffectSystem.cs
@@ -48,6 +48,8 @@ namespace Content.Server.EntityEffects;
 
 public sealed class EntityEffectSystem : EntitySystem
 {
+    private static readonly ProtoId<WeightedRandomFillSolutionPrototype> RandomPickBotanyReagent = "RandomPickBotanyReagent";
+
     [Dependency] private readonly AtmosphereSystem _atmosphere = default!;
     [Dependency] private readonly BloodstreamSystem _bloodstream = default!;
     [Dependency] private readonly ChatSystem _chat = default!;
@@ -854,7 +856,7 @@ public sealed class EntityEffectSystem : EntitySystem
             return;
 
         var chemicals = plantholder.Seed.Chemicals;
-        var randomChems = _protoManager.Index<WeightedRandomFillSolutionPrototype>("RandomPickBotanyReagent").Fills;
+        var randomChems = _protoManager.Index(RandomPickBotanyReagent).Fills;
 
         // Add a random amount of a random chemical to this set of chemicals
         if (randomChems != null)
diff --git a/Content.Server/Gateway/Systems/GatewayGeneratorSystem.cs b/Content.Server/Gateway/Systems/GatewayGeneratorSystem.cs
index 83471cdbc1..a88cf6b428 100644
--- a/Content.Server/Gateway/Systems/GatewayGeneratorSystem.cs
+++ b/Content.Server/Gateway/Systems/GatewayGeneratorSystem.cs
@@ -36,8 +36,9 @@ public sealed class GatewayGeneratorSystem : EntitySystem
     [Dependency] private readonly SharedSalvageSystem _salvage = default!;
     [Dependency] private readonly TileSystem _tile = default!;
 
-    [ValidatePrototypeId<LocalizedDatasetPrototype>]
-    private const string PlanetNames = "NamesBorer";
+    private static readonly ProtoId<LocalizedDatasetPrototype> PlanetNames = "NamesBorer";
+    private static readonly ProtoId<BiomeTemplatePrototype> BiomeTemplate = "Continental";
+    private static readonly ProtoId<DungeonConfigPrototype> DungeonConfig = "Experiment";
 
     // TODO:
     // Fix shader some more
@@ -101,7 +102,7 @@ public sealed class GatewayGeneratorSystem : EntitySystem
         var random = new Random(seed);
         var mapUid = _maps.CreateMap();
 
-        var gatewayName = _salvage.GetFTLName(_protoManager.Index<LocalizedDatasetPrototype>(PlanetNames), seed);
+        var gatewayName = _salvage.GetFTLName(_protoManager.Index(PlanetNames), seed);
         _metadata.SetEntityName(mapUid, gatewayName);
 
         var origin = new Vector2i(random.Next(-MaxOffset, MaxOffset), random.Next(-MaxOffset, MaxOffset));
@@ -111,7 +112,7 @@ public sealed class GatewayGeneratorSystem : EntitySystem
         };
         AddComp(mapUid, restricted);
 
-        _biome.EnsurePlanet(mapUid, _protoManager.Index<BiomeTemplatePrototype>("Continental"), seed);
+        _biome.EnsurePlanet(mapUid, _protoManager.Index(BiomeTemplate), seed);
 
         var grid = Comp<MapGridComponent>(mapUid);
 
@@ -183,7 +184,7 @@ public sealed class GatewayGeneratorSystem : EntitySystem
         var dungeonRotation = _dungeon.GetDungeonRotation(seed);
         var dungeonPosition = (origin + dungeonRotation.RotateVec(new Vector2i(0, dungeonDistance))).Floored();
 
-        _dungeon.GenerateDungeon(_protoManager.Index<DungeonConfigPrototype>("Experiment"), args.MapUid, grid, dungeonPosition, seed);
+        _dungeon.GenerateDungeon(_protoManager.Index(DungeonConfig), args.MapUid, grid, dungeonPosition, seed);
 
         // TODO: Dungeon mobs + loot.
 
diff --git a/Content.Server/Ghost/GhostSystem.cs b/Content.Server/Ghost/GhostSystem.cs
index 33de2c6f39..3e09d86189 100644
--- a/Content.Server/Ghost/GhostSystem.cs
+++ b/Content.Server/Ghost/GhostSystem.cs
@@ -74,6 +74,7 @@ namespace Content.Server.Ghost
         private EntityQuery<PhysicsComponent> _physicsQuery;
 
         private static readonly ProtoId<TagPrototype> AllowGhostShownByEventTag = "AllowGhostShownByEvent";
+        private static readonly ProtoId<DamageTypePrototype> AsphyxiationDamageType = "Asphyxiation";
 
         public override void Initialize()
         {
@@ -585,7 +586,7 @@ namespace Content.Server.Ghost
                         dealtDamage = playerDeadThreshold - damageable.TotalDamage;
                     }
 
-                    DamageSpecifier damage = new(_prototypeManager.Index<DamageTypePrototype>("Asphyxiation"), dealtDamage);
+                    DamageSpecifier damage = new(_prototypeManager.Index(AsphyxiationDamageType), dealtDamage);
 
                     _damageable.TryChangeDamage(playerEntity, damage, true);
                 }
diff --git a/Content.Server/Salvage/SalvageSystem.ExpeditionConsole.cs b/Content.Server/Salvage/SalvageSystem.ExpeditionConsole.cs
index a9d8314f57..aa501368de 100644
--- a/Content.Server/Salvage/SalvageSystem.ExpeditionConsole.cs
+++ b/Content.Server/Salvage/SalvageSystem.ExpeditionConsole.cs
@@ -8,8 +8,8 @@ namespace Content.Server.Salvage;
 
 public sealed partial class SalvageSystem
 {
-    [ValidatePrototypeId<EntityPrototype>]
-    public const string CoordinatesDisk = "CoordinatesDisk";
+    public static readonly EntProtoId CoordinatesDisk = "CoordinatesDisk";
+    public static readonly ProtoId<LocalizedDatasetPrototype> PlanetNames = "NamesBorer";
 
     private void OnSalvageClaimMessage(EntityUid uid, SalvageExpeditionConsoleComponent component, ClaimSalvageMessage args)
     {
@@ -28,7 +28,7 @@ public sealed partial class SalvageSystem
         var mission = GetMission(_prototypeManager.Index<SalvageDifficultyPrototype>(missionparams.Difficulty), missionparams.Seed);
         data.NextOffer = _timing.CurTime + mission.Duration + TimeSpan.FromSeconds(1);
 
-        _labelSystem.Label(cdUid, GetFTLName(_prototypeManager.Index<LocalizedDatasetPrototype>("NamesBorer"), missionparams.Seed));
+        _labelSystem.Label(cdUid, GetFTLName(_prototypeManager.Index(PlanetNames), missionparams.Seed));
         _audio.PlayPvs(component.PrintSound, uid);
 
         UpdateConsoles((station.Value, data));
diff --git a/Content.Server/Salvage/SpawnSalvageMissionJob.cs b/Content.Server/Salvage/SpawnSalvageMissionJob.cs
index cbce4dc692..8b5e9898ad 100644
--- a/Content.Server/Salvage/SpawnSalvageMissionJob.cs
+++ b/Content.Server/Salvage/SpawnSalvageMissionJob.cs
@@ -100,7 +100,7 @@ public sealed class SpawnSalvageMissionJob : Job<bool>
         destComp.Enabled = true;
         _metaData.SetEntityName(
             mapUid,
-            _entManager.System<SharedSalvageSystem>().GetFTLName(_prototypeManager.Index<LocalizedDatasetPrototype>("NamesBorer"), _missionParams.Seed));
+            _entManager.System<SharedSalvageSystem>().GetFTLName(_prototypeManager.Index(SalvageSystem.PlanetNames), _missionParams.Seed));
         _entManager.AddComponent<FTLBeaconComponent>(mapUid);
 
         // Saving the mission mapUid to a CD is made optional, in case one is somehow made in a process without a CD entity
diff --git a/Content.Server/StationEvents/Events/RandomSentienceRule.cs b/Content.Server/StationEvents/Events/RandomSentienceRule.cs
index 3d2e457a34..359c3edae4 100644
--- a/Content.Server/StationEvents/Events/RandomSentienceRule.cs
+++ b/Content.Server/StationEvents/Events/RandomSentienceRule.cs
@@ -11,6 +11,9 @@ namespace Content.Server.StationEvents.Events;
 
 public sealed class RandomSentienceRule : StationEventSystem<RandomSentienceRuleComponent>
 {
+    private static readonly ProtoId<LocalizedDatasetPrototype> DataSourceNames = "RandomSentienceEventData";
+    private static readonly ProtoId<LocalizedDatasetPrototype> IntelligenceLevelNames = "RandomSentienceEventStrength";
+
     [Dependency] private readonly IPrototypeManager _prototype = default!;
     [Dependency] private readonly IRobustRandom _random = default!;
     protected override void Started(EntityUid uid, RandomSentienceRuleComponent component, GameRuleComponent gameRule, GameRuleStartedEvent args)
@@ -72,8 +75,8 @@ public sealed class RandomSentienceRule : StationEventSystem<RandomSentienceRule
             station.Value,
             Loc.GetString("station-event-random-sentience-announcement",
                 ("kind1", kind1), ("kind2", kind2), ("kind3", kind3), ("amount", groupList.Count),
-                ("data", _random.Pick(_prototype.Index<LocalizedDatasetPrototype>("RandomSentienceEventData"))),
-                ("strength", _random.Pick(_prototype.Index<LocalizedDatasetPrototype>("RandomSentienceEventStrength")))
+                ("data", _random.Pick(_prototype.Index(DataSourceNames))),
+                ("strength", _random.Pick(_prototype.Index(IntelligenceLevelNames)))
             ),
             playDefaultSound: false,
             colorOverride: Color.Gold
diff --git a/Content.Shared/Body/Systems/SharedBodySystem.Parts.cs b/Content.Shared/Body/Systems/SharedBodySystem.Parts.cs
index 0917197e29..78d270ddc9 100644
--- a/Content.Shared/Body/Systems/SharedBodySystem.Parts.cs
+++ b/Content.Shared/Body/Systems/SharedBodySystem.Parts.cs
@@ -8,12 +8,14 @@ using Content.Shared.Damage;
 using Content.Shared.Damage.Prototypes;
 using Content.Shared.Movement.Components;
 using Robust.Shared.Containers;
+using Robust.Shared.Prototypes;
 using Robust.Shared.Utility;
 
 namespace Content.Shared.Body.Systems;
 
 public partial class SharedBodySystem
 {
+    private static readonly ProtoId<DamageTypePrototype> BloodlossDamageType = "Bloodloss";
     private void InitializeParts()
     {
         // TODO: This doesn't handle comp removal on child ents.
@@ -178,7 +180,7 @@ public partial class SharedBodySystem
         )
         {
             // TODO BODY SYSTEM KILL : remove this when wounding and required parts are implemented properly
-            var damage = new DamageSpecifier(Prototypes.Index<DamageTypePrototype>("Bloodloss"), 300);
+            var damage = new DamageSpecifier(Prototypes.Index(BloodlossDamageType), 300);
             Damageable.TryChangeDamage(bodyEnt, damage);
         }
     }
diff --git a/Content.Shared/Chat/SharedSuicideSystem.cs b/Content.Shared/Chat/SharedSuicideSystem.cs
index d341ea89a8..4b9eaf24b7 100644
--- a/Content.Shared/Chat/SharedSuicideSystem.cs
+++ b/Content.Shared/Chat/SharedSuicideSystem.cs
@@ -8,6 +8,8 @@ namespace Content.Shared.Chat;
 
 public sealed class SharedSuicideSystem : EntitySystem
 {
+    private static readonly ProtoId<DamageTypePrototype> FallbackDamageType = "Blunt";
+
     [Dependency] private readonly DamageableSystem _damageableSystem = default!;
     [Dependency] private readonly IPrototypeManager _prototypeManager = default!;
 
@@ -57,8 +59,8 @@ public sealed class SharedSuicideSystem : EntitySystem
         // We don't want structural damage for the same reasons listed above
         if (!_prototypeManager.TryIndex(damageType, out var damagePrototype) || damagePrototype.ID == "Structural")
         {
-            Log.Error($"{nameof(SharedSuicideSystem)} could not find the damage type prototype associated with {damageType}. Falling back to Blunt");
-            damagePrototype = _prototypeManager.Index<DamageTypePrototype>("Blunt");
+            Log.Error($"{nameof(SharedSuicideSystem)} could not find the damage type prototype associated with {damageType}. Falling back to {FallbackDamageType}");
+            damagePrototype = _prototypeManager.Index(FallbackDamageType);
         }
 
         var damage = new DamageSpecifier(damagePrototype, lethalAmountOfDamage);
diff --git a/Content.Shared/Humanoid/NamingSystem.cs b/Content.Shared/Humanoid/NamingSystem.cs
index a2085c6692..98afb34015 100644
--- a/Content.Shared/Humanoid/NamingSystem.cs
+++ b/Content.Shared/Humanoid/NamingSystem.cs
@@ -12,6 +12,8 @@ namespace Content.Shared.Humanoid
     /// </summary>
     public sealed class NamingSystem : EntitySystem
     {
+        private static readonly ProtoId<SpeciesPrototype> FallbackSpecies = "Human";
+
         [Dependency] private readonly IRobustRandom _random = default!;
         [Dependency] private readonly IPrototypeManager _prototypeManager = default!;
 
@@ -21,8 +23,8 @@ namespace Content.Shared.Humanoid
             // Some downstream is probably gonna have this eventually but then they can deal with fallbacks.
             if (!_prototypeManager.TryIndex(species, out SpeciesPrototype? speciesProto))
             {
-                speciesProto = _prototypeManager.Index<SpeciesPrototype>("Human");
-                Log.Warning($"Unable to find species {species} for name, falling back to Human");
+                speciesProto = _prototypeManager.Index(FallbackSpecies);
+                Log.Warning($"Unable to find species {species} for name, falling back to {FallbackSpecies}");
             }
 
             switch (speciesProto.Naming)