diff --git a/Resources/Prototypes/_Offbrand/reagents.yml b/Resources/Prototypes/_Offbrand/reagents.yml
index 44a98b143e..daacc170e2 100644
--- a/Resources/Prototypes/_Offbrand/reagents.yml
+++ b/Resources/Prototypes/_Offbrand/reagents.yml
@@ -8,9 +8,16 @@
   physicalDesc: reagent-physical-desc-opaque
   metabolisms:
     Medicine:
-      metabolismRate: 0.1
+      metabolismRate: 0.05
       statusEffects:
       - statusEffect: StatusEffectPainkillersMildParacetamol
+        conditions:
+        - !type:ReagentThreshold
+          reagent: Tramadol
+          max: 1
+        - !type:ReagentThreshold
+          reagent: Oxycodone
+          max: 1
       - statusEffect: StatusEffectPainkillersMildParacetamolOverdose
         conditions:
         - !type:ReagentThreshold
@@ -34,13 +41,16 @@
   physicalDesc: reagent-physical-desc-opaque
   metabolisms:
     Medicine:
-      metabolismRate: 0.1
+      metabolismRate: 0.05
       statusEffects:
       - statusEffect: StatusEffectPainkillersTramadol
       - statusEffect: StatusEffectPainkillersTramadolOverdose
         conditions:
         - !type:ReagentThreshold
           min: 15
+        - !type:ReagentThreshold
+          reagent: Oxycodone
+          max: 1
       - statusEffect: StatusEffectHeartStrainTramadolAlcohol
         conditions:
         - !type:ReagentThreshold
@@ -66,7 +76,7 @@
           min: 1
         damage:
           types:
-            Asphyxiation: 1
+            Asphyxiation: 0.75
 
 - type: reagent
   id: Oxycodone
@@ -78,7 +88,7 @@
   physicalDesc: reagent-physical-desc-opaque
   metabolisms:
     Medicine:
-      metabolismRate: 0.1
+      metabolismRate: 0.15
       statusEffects:
       - statusEffect: StatusEffectPainkillersStrongOxycodone
       - statusEffect: StatusEffectPainkillersStrongOxycodoneOverdose
@@ -102,7 +112,7 @@
           min: 15
         damage:
           types:
-            Asphyxiation: 1
+            Asphyxiation: 0.5
       - !type:HealthChange
         conditions:
         - !type:ReagentThreshold
@@ -110,7 +120,7 @@
           min: 1
         damage:
           types:
-            Asphyxiation: 3
+            Asphyxiation: 0.75
 
 - type: reagent
   id: Synthflesh
diff --git a/Resources/Prototypes/_Offbrand/status_effects.yml b/Resources/Prototypes/_Offbrand/status_effects.yml
index d4f5b9e797..0d24c8cd45 100644
--- a/Resources/Prototypes/_Offbrand/status_effects.yml
+++ b/Resources/Prototypes/_Offbrand/status_effects.yml
@@ -1,7 +1,7 @@
 - type: entity
   parent: MobStatusEffectBase
   id: StatusEffectPainkillersNegligibleBicaridine
-  name: negligible pain relief
+  name: 10 pain relief
   components:
   - type: PainkillerStatusEffect
     effectiveness: 10
@@ -13,15 +13,15 @@
 - type: entity
   parent: MobStatusEffectBase
   id: StatusEffectPainkillersMildParacetamol
-  name: mild pain relief
+  name: 15 pain relief
   components:
   - type: PainkillerStatusEffect
-    effectiveness: 25
+    effectiveness: 15
 
 - type: entity
   parent: StatusEffectPainkillersMildParacetamol
   id: StatusEffectPainkillersMildEthanol
-  name: mild pain relief and motor control dysfunction
+  name: 15 pain relief and motor control dysfunction
   components:
   - type: MeleeModifiersStatusEffect
     attackRateMultiplier: 0.95
@@ -32,7 +32,7 @@
 - type: entity
   parent: StatusEffectPainkillersMildParacetamolOverdose
   id: StatusEffectPainkillersMildEthanolOverdose
-  name: extra pain relief and worse motor control dysfunction
+  name: extra 10 pain relief and worse motor control dysfunction
   components:
   - type: MeleeModifiersStatusEffect
     attackRateMultiplier: 0.8
@@ -43,7 +43,7 @@
 - type: entity
   parent: MobStatusEffectBase
   id: StatusEffectPainkillersMildParacetamolOverdose
-  name: extra pain relief
+  name: extra 10 pain relief
   components:
   - type: PainkillerStatusEffect
     effectiveness: 10
@@ -51,18 +51,18 @@
 - type: entity
   parent: MobStatusEffectBase
   id: StatusEffectPainkillersTramadol
-  name: pain relief
+  name: 35 pain relief
   components:
   - type: PainkillerStatusEffect
-    effectiveness: 50
+    effectiveness: 35
 
 - type: entity
   parent: MobStatusEffectBase
   id: StatusEffectPainkillersTramadolOverdose
-  name: extra pain relief
+  name: extra 10 pain relief
   components:
   - type: PainkillerStatusEffect
-    effectiveness: 15
+    effectiveness: 10
 
 - type: entity
   parent: StatusEffectHeartStrainDesoxyephedrine
@@ -71,18 +71,18 @@
 - type: entity
   parent: MobStatusEffectBase
   id: StatusEffectPainkillersStrongOxycodone
-  name: strong pain relief
+  name: 50 pain relief
   components:
   - type: PainkillerStatusEffect
-    effectiveness: 75
+    effectiveness: 50
 
 - type: entity
   parent: MobStatusEffectBase
   id: StatusEffectPainkillersStrongOxycodoneOverdose
-  name: extra pain relief
+  name: extra 10 pain relief
   components:
   - type: PainkillerStatusEffect
-    effectiveness: 20
+    effectiveness: 10
 
 - type: entity
   parent: StatusEffectHeartStrainSedin