diff --git a/Content.Server/Body/Systems/MetabolizerSystem.cs b/Content.Server/Body/Systems/MetabolizerSystem.cs
index 5233b0166c..c8851b49ac 100644
--- a/Content.Server/Body/Systems/MetabolizerSystem.cs
+++ b/Content.Server/Body/Systems/MetabolizerSystem.cs
@@ -156,10 +156,9 @@ namespace Content.Server.Body.Systems
 
                 foreach (var group in meta.MetabolismGroups)
                 {
-                    if (!proto.Metabolisms.ContainsKey(group.Id))
+                    if (!proto.Metabolisms.TryGetValue(group.Id, out var entry))
                         continue;
 
-                    var entry = proto.Metabolisms[group.Id];
                     var rate = entry.MetabolismRate * group.MetabolismRateModifier;
 
                     // Remove $rate, as long as there's enough reagent there to actually remove that much
diff --git a/Content.Server/Chemistry/Commands/DumpReagentGuideText.cs b/Content.Server/Chemistry/Commands/DumpReagentGuideText.cs
index 70a79254d6..563708b8f3 100644
--- a/Content.Server/Chemistry/Commands/DumpReagentGuideText.cs
+++ b/Content.Server/Chemistry/Commands/DumpReagentGuideText.cs
@@ -36,7 +36,7 @@ public sealed class DumpReagentGuideText : IConsoleCommand
             return;
         }
 
-        foreach (var (_, entry) in reagent.Metabolisms)
+        foreach (var entry in reagent.Metabolisms.Values)
         {
             foreach (var effect in entry.Effects)
             {
diff --git a/Content.Server/GuideGenerator/ReagentEntry.cs b/Content.Server/GuideGenerator/ReagentEntry.cs
index 5c9ec40fd4..ab9e758206 100644
--- a/Content.Server/GuideGenerator/ReagentEntry.cs
+++ b/Content.Server/GuideGenerator/ReagentEntry.cs
@@ -32,7 +32,7 @@ public sealed class ReagentEntry
     public List<string> Recipes { get; } = new();
 
     [JsonPropertyName("metabolisms")]
-    public Dictionary<ProtoId<MetabolismGroupPrototype>, ReagentEffectsEntry>? Metabolisms { get; }
+    public Dictionary<string, ReagentEffectsEntry>? Metabolisms { get; }
 
     public ReagentEntry(ReagentPrototype proto)
     {
@@ -42,7 +42,7 @@ public sealed class ReagentEntry
         Description = proto.LocalizedDescription;
         PhysicalDescription = proto.LocalizedPhysicalDescription;
         SubstanceColor = proto.SubstanceColor.ToHex();
-        Metabolisms = proto.Metabolisms;
+        Metabolisms = proto.Metabolisms?.ToDictionary(x => x.Key.Id, x => x.Value);
     }
 }
 
diff --git a/Content.Server/Nutrition/EntitySystems/DrinkSystem.cs b/Content.Server/Nutrition/EntitySystems/DrinkSystem.cs
index e45c904591..e41c834c80 100644
--- a/Content.Server/Nutrition/EntitySystems/DrinkSystem.cs
+++ b/Content.Server/Nutrition/EntitySystems/DrinkSystem.cs
@@ -112,7 +112,7 @@ public sealed class DrinkSystem : EntitySystem
             if (reagent.Metabolisms == null)
                 continue;
 
-            foreach ((var _, var entry) in reagent.Metabolisms)
+            foreach (var entry in reagent.Metabolisms.Values)
             {
                 foreach (var effect in entry.Effects)
                 {
diff --git a/Content.Shared/Chemistry/Reagent/ReagentPrototype.cs b/Content.Shared/Chemistry/Reagent/ReagentPrototype.cs
index 1603d3d647..c9ce5f357c 100644
--- a/Content.Shared/Chemistry/Reagent/ReagentPrototype.cs
+++ b/Content.Shared/Chemistry/Reagent/ReagentPrototype.cs
@@ -1,4 +1,5 @@
-using System.Linq;
+using System.Collections.Frozen;
+using System.Linq;
 using System.Text.Json.Serialization;
 using Content.Shared.Administration.Logs;
 using Content.Shared.Body.Prototypes;
@@ -14,7 +15,6 @@ using Robust.Shared.Random;
 using Robust.Shared.Serialization;
 using Robust.Shared.Serialization.TypeSerializers.Implementations.Custom.Prototype;
 using Robust.Shared.Serialization.TypeSerializers.Implementations.Custom.Prototype.Array;
-using Robust.Shared.Serialization.TypeSerializers.Implementations.Custom.Prototype.Dictionary;
 using Robust.Shared.Utility;
 
 namespace Content.Shared.Chemistry.Reagent
@@ -103,7 +103,7 @@ namespace Content.Shared.Chemistry.Reagent
         public float Viscosity;
 
         [DataField(serverOnly: true)]
-        public Dictionary<ProtoId<MetabolismGroupPrototype>, ReagentEffectsEntry>? Metabolisms;
+        public FrozenDictionary<ProtoId<MetabolismGroupPrototype>, ReagentEffectsEntry>? Metabolisms;
 
         [DataField(serverOnly: true)]
         public Dictionary<ProtoId<ReactiveGroupPrototype>, ReactiveReagentEffectEntry>? ReactiveEffects;