diff --git a/Content.Shared/Alert/AlertType.cs b/Content.Shared/Alert/AlertType.cs
index 35409a2548..2a42b20d6f 100644
--- a/Content.Shared/Alert/AlertType.cs
+++ b/Content.Shared/Alert/AlertType.cs
@@ -32,6 +32,7 @@
         Pulling,
         Magboots,
         Toxins,
+        Muted,
         VowOfSilence,
         VowBroken,
         Debug1,
diff --git a/Content.Shared/Speech/Muting/MutedComponent.cs b/Content.Shared/Speech/Muting/MutedComponent.cs
new file mode 100644
index 0000000000..ff03be18a8
--- /dev/null
+++ b/Content.Shared/Speech/Muting/MutedComponent.cs
@@ -0,0 +1,6 @@
+namespace Content.Shared.Speech.Muting
+{
+    [RegisterComponent]
+    public sealed class MutedComponent : Component
+    {}
+}
diff --git a/Content.Shared/Speech/Muting/MutingSystem.cs b/Content.Shared/Speech/Muting/MutingSystem.cs
new file mode 100644
index 0000000000..0f3e89e91a
--- /dev/null
+++ b/Content.Shared/Speech/Muting/MutingSystem.cs
@@ -0,0 +1,21 @@
+using Content.Shared.Popups;
+using Robust.Shared.Player;
+
+namespace Content.Shared.Speech.Muting
+{
+    public sealed class MutingSystem : EntitySystem
+    {
+        [Dependency] private readonly SharedPopupSystem _popupSystem = default!;
+        public override void Initialize()
+        {
+            base.Initialize();
+            SubscribeLocalEvent<MutedComponent, SpeakAttemptEvent>(OnSpeakAttempt);
+        }
+
+        private void OnSpeakAttempt(EntityUid uid, MutedComponent component, SpeakAttemptEvent args)
+        {
+            _popupSystem.PopupEntity(Loc.GetString("speech-muted"), uid, Filter.Entities(uid));
+            args.Cancel();
+        }
+    }
+}
diff --git a/Resources/Locale/en-US/reagents/meta/narcotics.ftl b/Resources/Locale/en-US/reagents/meta/narcotics.ftl
index 13e39dce6f..8d913894cc 100644
--- a/Resources/Locale/en-US/reagents/meta/narcotics.ftl
+++ b/Resources/Locale/en-US/reagents/meta/narcotics.ftl
@@ -21,3 +21,6 @@ reagent-desc-space-drugs = An illegal compound which induces a number of effects
 
 reagent-name-nocturine = nocturine
 reagent-desc-nocturine = Makes you feel very tired and unable to stand up. Basically, it's bone hurting juice.
+
+reagent-name-mute-toxin = mute toxin
+reagent-desc-mute-toxin = Makes you unable to talk while metabolizing.
diff --git a/Resources/Locale/en-US/speech/speech-effects.ftl b/Resources/Locale/en-US/speech/speech-effects.ftl
new file mode 100644
index 0000000000..9f5ae07051
--- /dev/null
+++ b/Resources/Locale/en-US/speech/speech-effects.ftl
@@ -0,0 +1 @@
+speech-muted = You can't speak right now!
diff --git a/Resources/Prototypes/Alerts/alerts.yml b/Resources/Prototypes/Alerts/alerts.yml
index f4668347ed..064dd91717 100644
--- a/Resources/Prototypes/Alerts/alerts.yml
+++ b/Resources/Prototypes/Alerts/alerts.yml
@@ -191,6 +191,12 @@
   name: "[color=red]Parched[/color]"
   description: You're severely thirsty. The thirst makes moving around a chore.
 
+- type: alert
+  id: Muted
+  icon: /Textures/Interface/Alerts/Abilities/silenced.png
+  name: Muted
+  description: You have lost the ability to speak.
+
 - type: alert
   id: VowOfSilence
   icon: /Textures/Interface/Alerts/Abilities/silenced.png
diff --git a/Resources/Prototypes/Entities/Mobs/Species/human.yml b/Resources/Prototypes/Entities/Mobs/Species/human.yml
index 55b248480c..4f3129b534 100644
--- a/Resources/Prototypes/Entities/Mobs/Species/human.yml
+++ b/Resources/Prototypes/Entities/Mobs/Species/human.yml
@@ -82,6 +82,7 @@
     - Stutter
     - Electrocution
     - PressureImmunity
+    - Muted
   - type: DiseaseCarrier
   # Other
   - type: Inventory
diff --git a/Resources/Prototypes/Reagents/Consumable/Drink/alcohol.yml b/Resources/Prototypes/Reagents/Consumable/Drink/alcohol.yml
index 4de2436549..81f0a563b8 100644
--- a/Resources/Prototypes/Reagents/Consumable/Drink/alcohol.yml
+++ b/Resources/Prototypes/Reagents/Consumable/Drink/alcohol.yml
@@ -912,6 +912,14 @@
   physicalDesc: reagent-physical-desc-strong-smelling
   color: "#004666"
   spritePath: silencerglass.rsi
+  metabolisms:
+    Drink:
+      effects:
+      - !type:GenericStatusEffect
+        key: Muted
+        component: Muted
+      - !type:SatiateThirst
+        factor: 2
 
 - type: reagent
   id: Singulo
diff --git a/Resources/Prototypes/Reagents/narcotics.yml b/Resources/Prototypes/Reagents/narcotics.yml
index b740fed2b3..36eebd2141 100644
--- a/Resources/Prototypes/Reagents/narcotics.yml
+++ b/Resources/Prototypes/Reagents/narcotics.yml
@@ -152,3 +152,19 @@
         key: Stutter
         time: 1
         component: StutteringAccent
+
+- type: reagent
+  id: MuteToxin
+  name: reagent-name-mute-toxin
+  group: Narcotics
+  desc: reagent-desc-mute-toxin
+  physicalDesc: reagent-physical-desc-syrupy
+  color: "#000000"
+  boilingPoint: 255.0
+  meltingPoint: 36.0
+  metabolisms:
+    Narcotic:
+      effects:
+      - !type:GenericStatusEffect
+        key: Muted
+        component: Muted
diff --git a/Resources/Prototypes/Recipes/Reactions/chemicals.yml b/Resources/Prototypes/Recipes/Reactions/chemicals.yml
index c82d956be9..91f23f195b 100644
--- a/Resources/Prototypes/Recipes/Reactions/chemicals.yml
+++ b/Resources/Prototypes/Recipes/Reactions/chemicals.yml
@@ -91,7 +91,7 @@
     - !type:ExplosionReactionEffect
       explosionType: Default
       maxIntensity: 1 # at most 15 damage per tile
-      intensityPerUnit: 0.5 # 50+50 reagent for maximum explosion 
+      intensityPerUnit: 0.5 # 50+50 reagent for maximum explosion
       intensitySlope: 2
       maxTotalIntensity: 25
 
@@ -287,3 +287,16 @@
      amount: 1
   products:
     Ephedrine: 4
+
+- type: reaction
+  id: MuteToxin
+  impact: Medium
+  reactants:
+    Uranium:
+      amount: 2
+    Water:
+      amount: 1
+    Carbon:
+      amount: 1
+  products:
+    MuteToxin: 2 #Lower yield is intentional
diff --git a/Resources/Prototypes/status_effects.yml b/Resources/Prototypes/status_effects.yml
index d7acc7601b..9e36c423da 100644
--- a/Resources/Prototypes/status_effects.yml
+++ b/Resources/Prototypes/status_effects.yml
@@ -27,3 +27,7 @@
 
 - type: statusEffect
   id: PressureImmunity
+
+- type: statusEffect
+  id: Muted
+  alert: Muted